^(14)C-尿素呼吸试验检测消化专业医务人员HP感染及药物清除的观察

The Investigation of Prevalence of H. Pylori with^(14)C-urea Breath Test and Therapeutic Effect in Digestive Staffs

目的:了解从事消化专业的医务人员HP感染情况及药物清除疗效。方法:^(14)C-尿素呼吸试验检测天津医大三所附属医院消化内镜工作者及相关人员25名的HP感染情况。应用法莫替丁,替硝唑,枸橼酸铋胺,三联2周疗法对HP阳性者行根除治疗,同法检测根除疗效。结果:HP感染率为96%,高于文献报道普通人群的感染率。^(14)C-UBT放射活度测定值在医生组高于护技组,工作年限高于10年组高于短工作年限组。三联2周疗法HP根除率为73.75。结论:消化内镜工作人员对HP易感染,应注意对HP感染的预防。感染后药物根除治疗有效。

Objective:To investigate the prevalence of H.pylori (HP) and therapeutic effect in digestive staffs. Methods:The infection of HP were detected in 25 digestive endoscopists and relative staffs using 14 C-urea breath test (14 C-UBT). People with HP positive infection were treated with famotidine, tinidazole, bismuth, and ammonium citrate for 2 weeks. Results: The rate of infection of HP in endoscopists was 96 % , and was higher than that in regular people. The count of dpm 14 C-UBT was higher in doctor group than that in nurse and technician group, and it was higher in doctors with the experience more than 10 years than that with the experience less than 10 years. The rate of eradication against HP with the treatment of famotidine, tinidazole, bismuth, and ammonium citrate for 2 weeks was 73.7.%. Conclusion: The endoscopists are sensitive to HP. Prevention from infection of HP should be obtained for all endoscopists. Treatment of HP infection with medicine is effective.