CIAPIN1与P—gp在结肠癌中的表达及意义

Expression and Significance of CIAPIN1 and P -gp in Colorectal Carcinoma

目的探讨CIAPIN1与P—gp在散发型结肠癌中的表达及其与耐药性的关系。方法应用sP免疫组化法检测65例结肠癌组织标本中CIAPIN1与P—gP的分布和表达并分析其相关性。结果CIAPIN1与P—gP的阳性表达率分别为69．2％、52．3％，其表达不受性别、年龄、肿瘤部位、分化程度的影响，但不同Duke’s分期的癌组织中的表达有显著性差异（P〈0．05），相关分析显示二者表达呈显著正相关（P〈0．05）。结论CIAPIN1与P—gP在结肠癌进展中起重要作用，高表达CIAPIN1与P—gP的肿瘤组织具有较强的浸润与转移能力，并可能导致多药耐药的发生。

Objective To investigate the expression of CIAPIN1 and P - gp in sporadic colorectal carcinoma and the relationship with drug resistance. Methods Distribution and expression of CIAPIN1 and P - gp in 65 specimens with colorectal carcinoma were detected by SP immunohistochemical method. Results Positive rates of CIAPIN1 and P - gp were 69.2% and 52.3 % respectively, which were not correlated with gender, age,location and differentiation. However, there was significant difference in carcinoma at different Duke＇ stages （P 〈 0.05 ）. There was significant positive correlation between them by correlation analysis（ P 〈 0.01 ）. Conclusion CIAPIN1 and P - gp play an important role in the development of colorectal carcinoma. Carcinoma with high expression of CIAPIN1 and P - gp has strong ability of invasion and metastasis. They can also result in muhidrug resistance.