新生儿胼胝体大小及形状与胎龄的相关性研究

The relationship between the size, shape of corpus callosum and gestational age in neonatal infants

目的通过高场MRI检测不同胎龄新生儿出生时胼胝体的面积、偏心率及斜率,为早期评价和改善脑发育提供参考。方法从沧州市人民医院提取符合研究条件的新生儿头颅高场MRI图像286例,勾画胼胝体后使用MATLAB R2010a中的图像处理函数进行测量,得到胼胝体面积、偏心率及斜率并作统计学分析。结果胼胝体面积与胎龄的相关系数为0.61(P<0.001),最适曲线为二次曲线Y=0.132X2-6.179X+141.759,决定系数为0.37(P<0.001);偏心率与胎龄的相关系数为0.25(P<0.001),最适曲线为直线方程Y=0.009X+0.319,决定系数为0.07(P<0.001);后部斜率与胎龄的相关系数为0.27(P<0.001),最适曲线为直线方程Y=0.005X+0.349,决定系数为0.07(P<0.001)。结论新生儿胎龄愈小,胼胝体愈小且愈圆。

Objective The aim of this study was to study the pattern of callosal development by MRI to investigate neonatal corpus callosum size and shape in different gestational ages and to analyze the relationship between the area, eccentricity ratio and posterior skew of neonatal corpus callosum and gestational age, so that reference for early evaluation of the development of brain can be provided. Method 286 eligible high field brain MR images of neonates were selected. All corpus callosums were sketched in the MR images. And then, all data were analyzed by Image Processing Function of MATLAB R2010a. Corpus callosum area, eccentricity ratio and skew in 286 neonates were obtained and analyzed statistically, respectively. Result Pearson correlation analysis indicated the positive linear correlation between the corpus callosum area and gestational age （r=0.61, P〈0.001）. The corpus callosum area formed a quadratic curve with the gestational age, which was Y=0.132X：- 6.179X＋ 141.759（R2=0.37, P 〈 0.001）. Spearman rank correlation analysis indicated the positive linear correlation between the eccentricity ratio of corpus callosum and gestational age （r=0.25, P 〈 0.001）. The eccentricity ratio of corpus callosum formed a linear equation with the gestational age, which was Y=0.009X＋0.319 （R2=0.07, P 〈 0.001）. Pearson correlation analysis indicated the positive linear correlation between the skew of posterior corpus callosttm and gestational age （r=0.27, P 〈 0.001）. The skew of posterior corpus callosum formed a linear equation with the gestational age, which was Y= 0.005X＋0.349 （R2-0.07, P〈 0.001）. Conclusion The results of this study suggest that the smaller the gestational age of the newborn, the smaller and circular the corpus callosum.