摘要
采用高效液相色谱法测定防脱、育发类化妆品中的非那雄胺,色谱条件为ZorbaxExtendC18柱(250mm×4.6mm,5μm),流动相为乙腈/10mmol·L^-1磷酸二氢钾梯度洗脱体系,流速为1.0mL·min^-1,检测波长为220nm,柱温为30℃。实验结果表明,在此条件下非那雄胺在0.8~20mg·L^-1与相应的峰面积具有良好的线性关系(R^2=0.9990),回收率为90.3%~102.0%。
A reversed - phase high performance liquid chromatography for the determination of finasteride in anti -calvous hair cosmetics was established. The sample was analyzed on a Agilent Zorbax Extend Cts column (250 mm× 4.6 mm, 5 μm) with detecting wavelength of 220 nm at 30 ℃, and eluted by mobile phase composed of acetonitrile (CH3CN) and KH2PQ (10 mmol·L^-1) with a gradient model,at a flow rate 1.0 mL min ^-1. Results showed that as the mass concentration of finasteride is in the range of 0. 8 - 20 mg·L^-1, the relationship between the mass concentration and the corresponding peak area shows good linearity (R2 = 0. 999 0). The recoveries of finasteride achieve 90.3 % - 102. 0%.
出处
《日用化学工业》
CAS
CSCD
北大核心
2014年第1期54-56,共3页
China Surfactant Detergent & Cosmetics
关键词
发用化妆品
非那雄胺
高效液相色谱法
sterile hair cosmetics
finasteride
high performance liquid chromatography