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CD64对抗生素治疗烧伤感染的参考意义 被引量：2

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摘要 目的:探索外周血中性粒细胞CD64表达水平对烧伤患者应用抗生素的参考意义。方法:选择烧伤感染住院患者126例,按照性别、年龄、烧伤原因、吸入性损伤和烧伤指数(BI)进行配对设计,将患者随机分为CD64组和对照组(n=63)。CD64组根据中性粒细胞CD64作为开始和停用抗生素的依据;对照组按照常规方法应用抗生素。出院后统计两组抗生素疗程、抗生素费用、住院时间、住院费用和临床有效率。结果:CD64组抗生素疗程为(17.86±5.67)d,短于对照组(24.04±7.74)d(P<0.05)。CD64组的抗生素费用为(5 276.56±1 643.33)元,低于对照组(7 341.68±2 007.72)元(P<0.05)。两组住院时间、住院总费用、预后和临床有效率相比无明显差异(P>0.05),判断抗生素疗效的ROC曲线下面积(AUC)依次为CD64(0.896)>C反应蛋白(0.806)>中性粒细胞百分数(0.672)>白细胞计数(0.561)。结论 :烧伤感染时血中性粒细胞表面CD64表达水平可作为指导临床抗生素应用的参考指标,可以缩短抗生素使用疗程,降低抗生素费用。
作者 柳权 张立明 王润秀 蒙诚跃 欧斌贤 高兴新
机构地区 广西医科大学第一附属医院烧伤整形外科
出处 《实用医学杂志》 CAS 北大核心 2014年第3期419-421,共3页 The Journal of Practical Medicine
基金 广西医疗卫生重点科研项目(编号:重2012071)
关键词 烧伤 感染 抗生素 CD64
分类号 R644 [医药卫生—外科学]
  • 相关文献

参考文献7

  • 1赵丽丽,张立明,谭朝中,王润秀,蒙诚跃.CD64、C-反应蛋白对烧伤感染患者的临床诊断价值[J].实用医学杂志,2013,29(2):211-214. 被引量：22
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二级参考文献15

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共引文献24

同被引文献30

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实用医学杂志
2014年 第3期

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