酒渣鼻发病机制中微生物的作用

Roles of microorganisms in the pathogenesis of rosacea

酒渣鼻是一种常见的面部慢性炎症性皮肤病，其发病机制尚不明确，其中微生物起重要作用。蠕形螨虫与酒渣鼻发病有密切相关，可能通过Ⅳ型免疫反应致病。在对蠕形螨虫所携带的细菌的研究中，人们发现奥列伦芽胞杆菌、表皮葡萄球菌可能由蠕形螨虫携带，并与之共同致病；幽门螺杆菌、小肠细菌过度生长等可能在合并消化道症状的酒渣鼻发病中起作用，但其相关性和致病机制并不确切。目前尚未发现痤疮丙酸杆菌、沃尔巴克体与酒渣鼻发病有关。

Rosacea is a common chronic inflammatory skin disease that predominantly affects the central regions of the face. Its pathogenesis remains unknown, and microorganisms are considered to play an important role in its development. Demodex mites contribute a lot to the development of rosacea, probably through type IV immunological reaction. Bacillus oleronius and Staphylococcus epidermidis, which are found to be carried by Demodex mites, may synergistically collaborate with Demodex mites in the pathogenesis of rosacea. Besides, Helicobacter pylori and small intestinal bacterial overgrowth may be involved in the initiation of rosacea complicated by digestive tract symptoms, but the correlation and mechanisms remain unclear. There has been no evidence for the correlation between rosaeea and Propionibaeterium acnes or Wolbachia.