多中心网状组织细胞增生症研究进展

Multicentric reticulohistiocytosis： an update

多中心网状组织细胞增生症是一种罕见的肉芽肿性疾病，病因不明，临床表现多样，随着病情的发展，可出现多系统损害；诊断主要通过组织病理、免疫组化和影像学检查；目前尚无确切有效的治疗方法。该病最常累及皮肤、黏膜、关节，特征性病变为皮肤多个红褐色丘疹、结节和多发性、对称性、侵蚀性关节炎。

Muhicentrie reticulohistiocytosis （MRH） is a rare granulomatous disease of unknown etiology. The clinical manifestation of MRH is diverse, and multiple systems can be involved suring disease progression. Diagnosis is mainly based on histopathology, immunohistochemistry and imaging examination. There is still no effective treatment for MRH. Skin, mucous membrane and joints are most commonly involved, with multiple red-brown papules and nodules as well as multiple, symmetric and erosive arthritis as the characteristic lesions.