单倍体相合造血干细胞移植后重症移植物抗宿主病的护理

Nursing One Case with Severe Graft-Versus-Host Transplantation

目的探讨行单倍体相合造血干细胞移植（HSCT）后重症移植物抗宿主病（GVHD）的护理。方法选择2012年1月15日，第三军医大学附属第二医院血液科收治的1例单倍体相合HSCT后出现罕见移植物抗宿主病的患儿作为研究对象。在该患儿整个治疗过程中，注意病情观察及记录，给予全环境保护、全身皮肤黏膜的保护、外周中心静脉插管保护以及心理护理。结果患儿于移植后49天，无明显发热，口服止泻药治疗后，大便成形。全身皮肤恢复完整。结论对单倍体相合HSCT后重症GVHD的患儿进行及时有效的护理，可预防和减少并发症的发生，保证治疗成功。

Objective To investigate the nursing severe graft versus-host disease after haploidentical hematopoietie stem cell transplantation. Methods At January 15th 2012, one case with rare grab-versus- host disease （GHVD） after haploidentical hematopoietie stem cell transplantation （HSCT） in Xinqiao Hospital was included in this study. Throughout the whole course of treatment, patient＇s conditions were carefully observed and recorded, full protection, and full environmental protection, the protection of the body＇s skin and mucous membranes, peripheral central venous catheter protection and psychological care were performed. Results In 49 days after HSCT, no fever was found and forming stool was observed after oral antidiarrheal treatment. The whole body skin was integrity. Conclusions Timely and effective nursing care could prevent and reduce the occurrence of complications, and ensure successful treatment for severe GVHD after haploidentical HSCT.