摘要
目的:比较观察健康牙龈和慢性牙周炎牙龈组织中IL-23基因的表达水平。方法:选择活动期慢性牙周炎患者23例,牙周健康者15例,分别记录各受试牙的牙周临床指标后,采集牙龈组织标本,用实时定量PCR方法定量检测IL-23 mRNA在不同牙龈组织中的表达水平;并用Spearman秩相关分析IL-23与各牙周指标的相关关系。结果:慢性牙周炎组牙龈组织IL-23 mRNA表达量(0.0060±0.0034)显著高于正常对照组(0.0034±0.0018)(P<0.05);慢性牙周炎组牙龈组织中的IL-23 mRNA表达量与牙龈指数、牙周袋探诊深度、附着丧失水平均呈正相关(P<0.05)。结论:IL-23在慢性牙周炎发病机制中可能发挥重要作用。
AIM: To observe the expression of IL-23 mRNA in gingival tissues of chronic periodontitis patients. METHODS : Samples of gingival biopsies were collected from chronic periodontitis patients ( n = 23 ) and periodontally healthy individuals (n = 15). The IL-23 mRNA expression was examined by real-time PCR. Before sampiing, the clinical periodontal indices were recorded. RESULTS: A significant overexpression of IL-23 was detected in periodontal disease-affected tissues compared to healthy gingival tissues (0. 0060± 0.0034 vs 0.0034 ± 0. 0018, P 〈 0.05). The level of IL-23 expression in periodontitis tissues was positively correlated with gingival index, probing depth and attachment level( P 〈 0.05 ). CONCLUSION: IL-23 might play an important role in the pathogenesis of chronic periodontitis.
出处
《牙体牙髓牙周病学杂志》
CAS
北大核心
2014年第1期30-33,共4页
Chinese Journal of Conservative Dentistry