25例早期硬斑病的间质性浸润模式分析

Interstitial infiltration pattern in early morphea： clinicopathological analysis of 25 cases

目的探讨间质性浸润模式在早期硬斑病诊断中的意义。方法收集25例组织学炎症细胞表现为间质性浸润的硬斑病，分析其临床特点、组织学特征。结果患者平均发病时间为7．5个月，皮疹主要表现为水肿性的暗红色斑块，组织学以炎症细胞在胶原纤维间呈间质性浸润为主，经过抗炎治疗，70％的患者皮损消失或缓解。结论炎症细胞呈间质性浸润是早期硬斑病的一种少见组织学模式，了解并认识这种模式对该病的早期诊断及治疗有益。

Objective To estimate the diagnostic value of interstitial infiltration pattern for early morphea. Methods Twenty-five cases of early morphea pathologically characterized by interstitial infiltration of inflammatory cells were collected from 2010 to 2012. The clinicopathological features of these cases were retrospectively analyzed. Results The average clinical course was 7.5 months. The primary manifestation was edematous dark erythematous plaques, and interstitial or mixed infiltrate of inflammatory cells was the characteristic histopathological presentation. After anti-inflammatory treatment, lesions markedly improved or disappeared in 70% of these patients. Conclusions Interstitial infiltration of inflammatory cells is a rare histologic pattern in early morphea. To learn and recognize this pattern may be beneficial to the diagnosis and treatment of early morphea.