调整紫杉醇化疗预处理方案的临床观察

Clinical observation of paclitaxel chemotherapy by premedication procedure adjusted

目的观察不同紫杉醇预处理方案化疗的用药安全性和不良反应,探索新的紫杉醇化疗预处理方案。方法紫杉醇135～175 mg/m2,联合铂类药物,21 d/周期,输注紫杉醇前用2种预处理方案,比较应用2种预处理方案化疗的不良反应。结果 77例应用调整预处理方案的患者与78例标准预处理方案患者的急性过敏反应、神经毒性、胃肠道反应发生率比较均无差异。结论调整后的紫杉醇预处理方案安全、有效,与标准预处理方案比较无差异。

Objective To observe the drug safety and adverse reactions of the different paclitaxel premedication, to explore a new paclitaxel premedication procedure. Methods Two kinds of the premedication procedure was used before injection of paclitaxel, one in standard premedication procedure, the another in adjusted premedication pro- cedure, to observe the drug safety and adverse reactions of the different paclitaxel premedication procedure, then explore a new paclitaxel premedication procedure. Results The acute allergic reaction, neurotoxicity, gastrointes- tinal reaction rates were not statistically significant between the group in application of adjustment premedication procedure and the group in standard premedication procedure. Conclusions The adjusted paclitaxel premedication procedure is safety and effective.