内皮祖细胞与肢体缺血疾病的研究现状

The current research status of endothelial progenitor cells and limb ischemia diseases

肢体缺血性疾病已成为发达国家及许多发展中国家的主要疾病之一,而干细胞移植是治疗肢体缺血性疾病备受关注的新方法。内皮祖细胞(EPCs)可分化为内皮细胞,参与新生血管生成。研究证实,体内移植EPCs可以促进缺血后组织内的血管新生,为缺血性疾病治疗提供了新策略。

Limb ischemic disease has become one of the major diseases in developed countries as well as many developing countries. The stem cell transplantation is a new method for treatment of limb ischemic diseases and it has attracted much attention. Endothelial progenitor cells （EPCs） can differentiate into endothelial cells involved in angiogenesis. Many reports have confirmed that the transplanted EPCs in the body can promote angiogenesis in ischemic tissue