血清胰岛素样生长因子-1和胰岛素样生长因子结合蛋白-3在川崎病中的作用

Effect of serum insulin-like growth factor-1 and insulin-like growth factor binding protein-3 on coronary artery lesion in Kawasaki disease

目的:探讨血清胰岛素样生长因子-1(IGF-1)和胰岛素样生长因子结合蛋白-3(IGFBP-3)在川崎病发生及冠状动脉损伤(CAL)中的作用。方法:采用化学发光法检测52例川崎病患儿(川崎病组)血清IGF-1及IGFBP-3水平,设32例同期住院的感染性疾病患儿为发热对照组,并将川崎病组分为CAL亚组15例及non-CAL亚组37例,对各组患儿IGF-1及IGFBP-3水平进行分析比较。结果:52例川崎病组血清IGF-1水平增高,与发热对照组比较差异有统计学意义(P<0.05),血清IGFBP-3水平两组间比较无统计学差异(P>0.05)。CAL亚组血清IGF-1水平较non-CAL亚组明显增高,差异具有统计学意义(P<0.01),血清IGFBP-3水平两亚组间比较差异无统计学意义(P>0.05)。结论:IGF-1在川崎病急性期并发CAL时明显增高,对早期预测冠状动脉病变有一定意义。

Objective：To explore the serum insulin-like growth factor-1（IGF-1）and insulin-like growth factor binding protein-3（IGFBP-3）on coronary artery lesion（CAL）in Kawasaki disease（KD）.Method：The 32 healthy children were set in the control group,and 52 patients with Kawassaki disease were set in KD group.Fifteen patients with CAL were set in CAL subgroup,and 37patients without CAL were set in non-CAL group.We analyzed and compared the serum IGF-1and IGFBP-3in different groups.Result：IGF-1and IGFBP-3levels in KD patients had statistical differences than those in control group（P0.05）,and IGF-1 and IGFBP-3 level of CAL subgroup had statistical differences than those in non-CAL group（P0.01）.However,IGBF-3level had no statistical difference（P0.05）.Conclusion：The levels of serum IGF-1in KD children increase significantly in acute phase,which can be used as a predictor of CALs in KD children.