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冠心病患者血浆白细胞介素-35水平及临床意义的探讨 被引量：7

The plasma IL-35 levels in patients with coronary heart disease and its clinical significance
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摘要 目前认为抗炎性细胞因子与促炎性细胞因子之间的失平衡最终导致动脉粥样硬化的进展、斑块的不稳定以及急性缺血事件的发生[1-3]。2007年,Niedbala等[4]和Collison等[5]分别发表了关于IL-35的文章,证实IL-35是由两个亚基IL-12α链p35和IL-27β链EBI3以二硫键共价连接而成。 This study was designed to observe the change of the plasma IL-35 levels in patients with different type of coronary heart disease（CHD）and analyzed its correlation with coronary gensini score,high-sensitive Creactive protein（hs-CRP）and NT-proBNP.The results showed that plasma IL-35 levels were significantly decreased in the SAP group,the UAP group,and the AMI group compared with the patients in control group[（95.71±4.05）vs（111.44±4.57）,P0.001;（45.00±3.18）vs（111.44±4.57）,P0.001;（28.25± 3.19）vs（111.44±4.57）,P0.001,respectively].Furthermore,lower IL-35levels were moderately negatively correlated with NT-proBNP（r=-0.567,P0.01）and hs-CRP（r=-0.718,P0.01）in CHD patients, whereas the levels of IL-35were not related to the Gensini score.
作者 台适 周胜华 刘启明 胡信群 方臻飞 唐亮
机构地区 中南大学湘雅二医院心内科长沙
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2014年第1期81-84,共4页 Journal of Clinical Cardiology
关键词 冠心病 白细胞介素-35 高敏C反应蛋白 N末端脑钠肽前体 动脉粥样硬化 coronary disease interleukin-35 high sensitive-C reaction protein NT-proBNP atherosclerosis
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献16

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共引文献8

同被引文献70

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引证文献7

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临床心血管病杂志
2014年 第1期

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