摘要
大量研究已证实肿瘤干细胞是肿瘤耐药、复发和转移的根源.慢性炎症与肿瘤的发生和发展密切相关,肿瘤炎性微环境中的IL-6、IL-8、EGF等炎性因子和生长因子激活了肿瘤干细胞内NF-κB/Stat3信号通路,维持肿瘤干细胞的自我更新能力,从而促进肿瘤的生长和转移.深入研究肿瘤炎性微环境对肿瘤干细胞的调控机制,可以使我们找到潜在的治疗靶点,为攻克肿瘤带来新的思路和手段.
Abstract Cancer stem cells have been suggested to play key role in tumor relapse, drug-resistance and metastasis. Chronic inflammatory states have been associated with an increased risk of malignancy. Therefore, it is possible that cytokines associated with chronic inflammation, such as IL-6, IL-8 and EGF, regulate the self-renewal of cancer stem cells via NF-KB/ Stat3 pathways. In this review, we will discuss how these adaptive processes potentially become subverted to enhance the development and function of cancer stem ceils.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2014年第1期52-57,共6页
Progress In Biochemistry and Biophysics
基金
国家重点基础研究发展计划(973)资助项目(2013CB967202)~~
