早期类风湿性关节炎血清学指标与腕关节滑膜MRI表现的相关性研究

Correlation Analysis of Serological Markers with Wrist Synovium MRI Findings in Early Rheumatoid Arthritis

目的:探讨早期类风湿性关节炎血清学指标与腕关节滑膜MRI表现之间的相关性。方法:对经临床诊断为早期类风湿性关节炎的24例患者的腕关节MRI和血清学检查资料进行总结,根据MRI上腕关节滑膜病变评分分值来分组比较血清学指标(CRP、IgA、IgG和IgM值)之间有无差异性。结果:24例早期类风湿性关节炎腕关节MRI上滑膜不同程度增厚并明显强化。滑膜病变评分值≥1.5分组(11例)和分值<1.5分组(13例)间IgA、IgG和IgM值差异有统计学意义(P<0.05),而CRP值差异无统计学意义(P>0.05)。结论:早期类风湿性关节炎的血清IgA、IgG和IgM值与腕关节MRI滑膜病变评分分值密切相关,而CRP值与腕关节MRI滑膜病变评分分值无关。

Objective：To investigate the correlation of serological markers with wrist synovium MRI findings in early rheumatoid arthritis（RA）. Method：The data of wrist MRI and serological examinations were reviewed in 24 cases of clinically diagnosed early RA patient. The difference of the value of serological markers,including CRP,IgA,IgG and IgM,were compared in the patients with different wrist synovial scores on MRI. Result：The wrists MRI showed the synovial thickening in varying degrees and significant enhancement after Gd-DTPA injection in 24 cases of early RA. The group of synovial scores≥1.5（11 cases）and the group of scores〈1.5（13 cases）were divided according to the wrist synovial scores on MRI. IgA,IgG and IgM values in the group of synovial scores more than 1.5 were significantly higher than that in the group of score less than 1.5（P〈0.05）. There was no significant difference of CRP value in the two groups（P〉0.05）. Conclusion：The serum IgA,IgG and IgM values are associated with wrist synovial scores on MRI. However,the serum CRP levels have no correlation with wrist synovial scores on MRI in the early RA.