磺胺邻二甲氧嘧啶在牙鲆体内的代谢动力学

Pharmacokinetics of sulfadimoxine in olive flouder Paralichthys olivaceus

采用超高效液相色谱法(UPLC)测定磺胺邻二甲氧嘧啶(Sulfadinoxine,SDM’)在牙鲆Paralichthy solivaceus血浆、肌肉和肝脏中浓度随时间的变化,通过DAS 2.0版药物代谢动力学软件研究了SDM’在牙鲆体内的药代动力学。研究结果表明,以200mg/kg的剂量进行单次口灌,SDM’在血浆、肌肉和肝脏中的代谢过程均符合二室模型,药-时曲线呈现单峰变化;达到Cmax的时间分别是24、24、8h,Cmax分别是158.09、43.04和6.71mg/kg;消除半衰期分别为48.9、501.5和116.1h。SDM’在牙鲆体内消除较慢,残留时间较长。

The pharmacokinetics of sulfadimoxine （SDM＇） in plasma, muscle and liver tissues of Paralichthys olivaceus were analyzed by UPLC after oral administration of 200 mg/ kg SDM＇ at a single dose. The results showed that the SDM＇ concentrations in plasma, muscle and liver of P. olivaceus were best described as a two-compartment model by DAS 2.0. The time to reach the maximum concentration in plasma, muscle and liver was 24, 24 and 8h, and the CmaxWaS 158. 09, 43. 04 and 6.71 mg/kg, respectively. The elimination half life turned out to be 48.9, 501.5 and 116.1 h. The residual time of SDM＇ in P. olivaceus was very long.