组织工程化口腔黏膜研究进展

Research progress of tissue-engineered oral mucosa

口腔黏膜或身体其他部位病变导致较大面积黏膜缺损,都需要有适合的移植材料来修复.组织工程方法可以提供解决这一问题的有效途径,而且通过组织工程方法构建的等效全层黏膜组织还可以成为评价口腔材料、黏膜用药以及口腔黏膜癌变的理想模型.探讨了黏膜组织工程的种子细胞来源以及脱细胞真皮基质、胶原类、纤维蛋白凝胶以及生物高分子电纺丝网状支架材料等黏膜组织工程基本问题,也对用于黏膜修复和黏膜模型的组织工程化口腔黏膜应用研究进行了阐述.

Large area defect of intra-oral or extra-oral mucosa caused by mucosa lesions need suitable graft materials for repair.Tissue engineering methods can provide effective pathway to resolve this problem.Furthermore,full thickness mucosa equivalent constructed by tissue engineering methods also can be used as a model to evaluate dental materials,drug delivery system and oral carcinogenesis.Basic issues of tissue-engineered mucosa including sources of seed cells,scaffold materials such as de-epidermised acellular dermis,collagens,fibrin glue and biomacromolecule electrostatic spinning are discussed in this review,and the application researches of tissueengineered mucosa for mucosa reconstruction and mucosa model equivalents are expounded too.