无乳链球菌黏附因子研究进展

Progress on Adhesion Factors of Streptococcus agalactiae

无乳链球菌是引起奶牛乳房炎的重要致病菌之一,医学上亦称B群链球菌(GBS),可引起新生儿、孕妇、老年人及免疫功能不全者发病甚至死亡。无乳链球菌的致病机制是目前研究的热点之一。无乳链球菌黏附于宿主细胞表面对其进一步的定植和入侵至关重要,黏附因子在该过程中起重要作用。论文对GBS纤维蛋白原结合蛋白、层黏连蛋白结合蛋白、丝氨酸重复蛋白、有免疫原性的细菌黏附蛋白和αC蛋白5个黏附因子的相关研究进行综述,深入阐述该病原菌的黏附定植机制。

Streptococcus agalactiae is regarded as an important cause of intramammary infection in cows, which is also named group B streptococci （GBS） in human causing a significant threat in newborns, preg- nant women, elderly and immunocompromised people. The pathogenic mechanism of Streptococcus aga- lactiae has been attracted considerable attention, and adhesion factors play an important role in the process of adhesion, which is important for mucosal colonization and subsequent invasion. In this review, the ad- hesion and colonization mechanism of Streptococcus agalactiae was elaborated by reviewing recent informa- tion on the five adhesion factors including fibrinogen-binding proteins, laminin-binding protein, serine-rich repeat proteins, GBS immunogenic bacterial adhesion and aC protein.