紫癜颗粒定性鉴别研究

Study on Qualitative Identification of Effective Components in New Traditional Chinese Medicine for Treating Purpura

目的建立紫癜颗粒的薄层色谱鉴别方法。方法采用薄层色谱法对制剂中的黄芪、大黄、甘草、当归进行定性鉴别。结果薄层色谱能检出黄芪、大黄、甘草、当归,且阴性对照均无干扰。结论该法简便易行、专属性强、重现性好,可用于本制剂的质量控制。

Objective：To assess whether a platelet rebound exists in patients with percutaneous coronary interventions（PCI）after clopidogrel discontinuation and the influences of different clopidogrel discontinue schedule on platelet aggregation and CD62P.Method：The 103 patients who underwent PCI and coming to the end of their 12 months course of clopidogrel therapy were divided into two discontinuation strategies,group A：abrupt drug cessation;or group B：clopidogrel was withdrawn in 3 months.Platelet aggregation and CD62 Pwere measured at four time-points（before clopidogrel treatment,1 week before clopidogrel stopped,1 week after clopidogrel stopped and 1 month after clopidogrel stopped）.Result：Platelet aggregation increased in both groups 1week after clopidogrel discontinuation.There were significant differences compared with those of baseline（P0.05）.Platelet aggregation returned to the baseline 1week after clopidogrel discontinuation in group B,but in group A,platelet aggregation returned to the baseline 1 month after clopidogrel discontinuation.There was no CD62Prebound in either groups.Conclusion：There is transient period of increased platelet reactivity 1week after clopidogrel discontinuation,but no changes of CD62 Pare observed.