摘要
目的探讨检测老年全身炎症反应综合征(SIRS)患者血清中降钙素原(PCT)及可溶性髓样细胞触发性受体-1(sTREM-1)的临床应用价值。方法 89例临床诊断为老年SIRS患者为SIRS组,其中发展为多器官功能障碍综合征(MODS)的患者27例为MODS组,40例健康体检者为对照组,用酶联免疫分析法检测PCT及sTREM-1,同时采集抗凝血检测白细胞。比较SIRS组、MODS组及对照组间上述各指标的差异。结果 SIRS组、MODS组的血清PCT、sTREM-1的水平及白细胞计数均明显高于对照组(P均<0.01);MODS组的PCT和sTREM-1水平明显高于SIRS组(P<0.05,P<0.01),白细胞计数两者相近(P>0.05)。结论血清中PCT、sTREM-1水平在SIRS、MODS患者及正常人中差异显著,二者均可作为老年SIRS的早期诊断和病情判定指标。
Objective To explore the clinical applied value of serum procalcitonin (PCT) and soluble triggering receptor expressed on myeloid cells-1 ( sTREM-1 ) among the elder patients with systemic inflammatory response syndrome ( SIRS ). Methods Eighty-nine elder SIRS patients ( SIRS group ) including 27 patients progressing into muhipleorgan dysfunctions syndrome(MODS) in them (MODS subgroup)were selected as research objects, and 40 healthy check-up persons were served as control group. Serum PCT and sTREM-1 were detected by enzyme-linked immunosorbent assay (ELISA). Meanwhile, the anti-coagulated blood was collected to detect white blood count (WBC) using auto-hemocytometer. The levels of PCT, sTREM-1 and WBC were compared among three groups. Results The levels of serum PCT,sTREM-1 and WBC in SIRS group and MODS subgroup were all higher than those in control group ( all P 〈 0.01 ). The levels of PCT and sTREM-1 in MODS subgroup were higher than those in SIRS group ( P 〈 0.05, P 〈 0.01 ), while WBC in SIRS group and MODS subgroup was similar ( P 〉 0.05 ). Conclusions There are significant differences in the values of PCT and sTREM-1 among the SIRS, MODS patients and healthy subjects, and they may all be served as the marks for early diagnosis of SIRS and judging state of illness.
出处
《中国临床研究》
CAS
2014年第1期19-20,23,共3页
Chinese Journal of Clinical Research
关键词
全身炎症反应综合征
降钙素原
可溶性髓样细胞触发性受体-1
白细胞计数
Systemic inflammatory response syndrome
Procalcitonin
Soluble triggering receptor expressedon myeloid cells-1
White blood count