临床基因诊断实验室的优化设计

Optimal design of clinical gene diagnosis laboratory

目的:对临床基因诊断实验室进行优化设计,保障基因扩增检验质量和生物安全,为今后相关实验室的设计改造积累方法和经验。方法:合理改造临床基因诊断实验室的结构,优化设计各实验操作区抽风系统,设置固定各室人员及室间的传递窗。结果:临床基因诊断实验室的优化设计,提高了各实验步骤中样品、模板及试剂等检测结果的准确性,减少了待检标本中传染性病原微生物可能对人员健康和环境产生的危害和污染,保障人员、环境的生物安全。结论:实验室布局合理、使用方便及系统配置完善,可保证基因诊断结果的准确性和安全性。

Objective： Optimal design of clinical gene diagnosis laboratory, ensure the gene amplification testing quality and protect biological safety, and accumulated a lot of experience and method for the design and improvement of future related laboratory. Methods： By reasonable structural transformation and arrangement to achieve clinical genetic diagnostic laboratories zoning requirements. Relying on the ventilation system of each experiment operating area, each operation achieved a relative buffer zone to form a relatively negative pressure to each chamber airflow unidirectional flow. It achieved a one-way flow of sample templates and reagents through fixed each room staff and setting up room transfer window.