视神经脊髓炎患者血清水通道蛋白4抗体水平与临床特征的相关性

The relevance of serum aquaporin-4 antibody level with the clinical features of neuromyelitis optica

目的探讨视神经脊髓炎(neuromyelitits optica,NMO)患者急性期血清水通道蛋白4(aquaporin-4,AQP-4)抗体水平与临床特征的相关性。方法利用荧光免疫沉淀法(fluorescence immunoprecipitation assay,FIPA)对作者医院确诊的78例NMO患者血清AQP-4抗体进行定量检测,研究抗体水平与临床特征的相关性。结果 (1)在78例NMO患者中,血清AQP-4抗体的阳性率为73.1%。(2)Spearman相关分析显示,EDSS评分、脊髓受累节段数、头MRI病灶数均与血清AQP-4抗体水平呈正相关(r=0.423,P=0.0001;r=0.355,P=0.002;r=0.286,P=0.022)。至下一次复发间隔时间与血清AQP-4抗体水平无明显相关性(r=-0.126,P=0.532)。结论 AQP-4抗体水平与NMO疾病严重程度有一定相关性,但急性期血清AQP-4抗体水平预测疾病复发的意义可能不大。

Objective To investigate the correlation between the aquaporin-4 （AQP-4） antibody titres and clinical characteristics in patients suffering from acute neuromyelitis optica （NMO）.Methods Quantitative detection of the sera AQP-4 antibody of the 78 NMO patients in our hospital by fluorescence immunoprecipitation assay （FIPA） was performed and the relation of AQP-4 antibody titres and clinical parameters was analyzed.Results （1） Among the 78 patients suffering form NMO,the seropositivity rate of sera AQP-4 antibody was 73.1％.（2） By Spearman analysis,it was obvious that EDSS scores,numbers of segments of spinal cord involved and brain MRI lesions were positively correlated to AQP-4 antibody levels （r=0.423,P=0.0001; r=0.355,P=0.002; r=0.286,P=0.022）.But the sera AQP-4 antibody level did not correlate with the interval period to the next attack （r=-0.126,P=0.532）.Conclusions The AQP-4 antibody titres in acute phase can indicate the severity of disease,but may not have predictive value for the relapse.