重症缺血性脑卒中危险因素分析

Analysis of the risk factors leading to severe ischemic stroke

目的 探讨导致重症缺血性脑卒中（sIS）发生的危险因素.方法 回顾性分析143例缺血性脑卒中（IS）患者的基本信息,包括既往病史、血常规、血生化、凝血象等指标,以及头部CT或MRI等影像学资料,根据美国国立卫生研究院卒中量表（NIHSS）对病情严重程度进行判断与分类.结果 143例IS患者中,sIS患者82例（57.3％）,轻症者61例（42.7％）.单因素分析结果显示sIS组和轻症IS组间既往脑卒中史、房颤、三酰甘油水平比较差异有统计学意义（P＜0.05）.经Logistic回归分析显示,既往脑卒中史（OR=3.39,95％CI为1.384～8.29）,房颤（OR=6.67,95％CI为2.20～20.25）,三酰甘油降低（OR-1.31,95％CI为1.04～2.73）与sIS的发生密切相关.结论 房颤、既往脑卒中史及三酰甘油水平降低是导致sIS发生的独立危险因素.

Objective To observe the risk factors leading to severe ischemic stroke （sIS）.Methods The basic information of 143 cases with ischemic stroke （IS） was analyzed retrospectively,including the previous history,blood routine,blood biochemistry,coagulation index etc.And the information of the cranial CT or MRI were collected.According to the National Institute of Health Stroke Scale （NIHSS）,the severity of the ischemic stroke was judged and classified.Results Among the 143 patients,there were 82 （57.3％） patients who had sIS and 61 （42.7 ％） patients who had mild ischemic stroke （mIS）.During the analysis of single factor between the two groups,atrial fibrillation,history of stroke and hypertriglyceridemia （TG） had statistical significance （P＜0.05）.Logistic regression analysis revealed that history of stroke （OR =3.39,95 ％ CI：1.384-8.29）,atrial fibrillation （OR=6.67,95％CI：2.20-20.25）,TG reduced （OR=1.31,95％CI：1.04-2.73） were closely related to sIS.Conclusions Atrial fibrillation,history of stroke and TG reduced are the independent risk factors leading to sIS.