前摄宁颗粒抗炎镇痛和体内抗菌作用研究

Effects of Anti-infl ammation, Ache Easing and Antibacteria in vivo of Qianshening Granules

目的研究前摄宁颗粒抗炎镇痛及其体内抗菌作用效果。方法采用大鼠棉球肉芽肿法,二甲苯致小鼠耳廓肿胀法及小鼠扭体反应法三种动物模型,观察前摄宁颗粒抗炎镇痛效果,应用小鼠腹腔注射金黄色葡萄球菌进行体内抑菌作用实验。结果前摄宁颗粒明显抑制异物(棉球)刺激引起的大鼠肉芽组织增生及二甲苯所致小鼠耳廓肿胀作用,并具有一定的量效关系。前摄宁颗粒高剂量(8.0g/kg.d)组能明显抑制醋酸引起的小鼠扭体反应次数,延长扭体潜伏期。前摄宁颗粒预防给药或治疗给药,对金黄色葡萄球菌引起的小鼠死亡率均有一定的抑制作用,但尚未达到统计差异(P>0.05),提示前摄宁颗粒直接的体内抗菌作用较弱。结论前摄宁颗粒具有较好的抗炎镇痛作用,但体内直接抗菌作用较弱。

Objective To study the effects of inflammation resisting, ache easing and antibacteria in vivo of Qianshening Granules. Methods Acestoma of rats caused by cotton ball and auricular edema of mice caused by xylol were used to observe the effects of inflammation resisting of Qianshening Granules. Mouse twisting method was adopted to observe the ache easing effect of Qianshening Granules and antibacterial effect was also tested in vivo. Results Qianshening Granules obviously restrained the auricular edema of mice and acestoma of rats with dose-dependent tendency, respectively. High dose group of Qianshening Granules （8.0g/kg.d） inhited the number of times of mice body twisting and postponed latent period of twisting. Qianshening Granules did not exhibited definite antibacterial effect ＆ vivo. Conclusion Qianshening Granules showed obvious therapeutic effects in ache easing and inflammation resisting, but did not exhibite definite antibacterial effect in vivo.