自发热无铅丁桂膏的制备

The Preparation of Self-heating and Unleaded Dinggui Paste

目的优化自发热材料各组分的配比,以其作为无铅丁桂膏的裱褙材料,制作成自发热无铅丁桂膏。方法按L16(45)五因素四水平正交试验表设计实验,对最高温度、平均温度、启动时间、持续时间进行综合评分,评分结果采用spss17.0统计软件进行数据分析。结果自发热材料的最佳配比为:还原铁粉:活性炭:氯化钠:蛭石:水=6:8:4:2:1。其中还原铁粉具有显著性差异(P<0.05)。结论以最佳配比制成的自发热材料能适度软化膏药,以其为裱褙材料制成的自发热无铅丁桂膏在使用时无需加热,接触空气后,缓缓散发热量,发挥药物和热敷的双重作用,适应临床需要。

Objective To optimize the ratio of the components of the self-heating material,taking it as the backing material to produce a self-heating and unleaded Dinggui paste. Methods To design experiments by the L16 （4^5） five factors and four levels of orthogonal test table, composite the score of maximum temperature, average temperature, start time and duration and use SPSS 17.0 statistical software for data analysis. Results The best ratio of self-heating material is reduced iron powder： carbon： sodium chloride： vermiculite： water = 6：8：4：2：1. Of which reduced iron powder has significant impact on the results （P〈0.05）. Conclusion The self-heating material made of the best ratio can soft the plaster moderately, and the self-heating and unleaded Dinggui paste made of this backing material do not require heating, because it can warm slowly when it contacts with air.This Dinggui Paste meets the clinical needs by playing the dual role of drugs and hot.