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黄芪注射液对实验性自身免疫性脑脊髓炎大鼠IFN-γ的影响 被引量：1

EFFECTS OF ASTRAGALUS INJECTION ON THE EXPRESSION OF IFN-ΓIN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN RATS
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摘要 目的探讨黄芪注射液对实验性自身免疫性脑脊髓炎(EAE)大鼠血清IFN-γ表达的影响。方法利用新鲜豚鼠全脊髓匀浆+完全福氏佐剂免疫Wistar大鼠建立实验性自身免疫性脑脊髓炎模型,选用黄芪注射液干预治疗,观察其对大鼠发病率、神经功能评分和病理学改变的影响,并检测血清IFN-γ的水平。结果黄芪注射液治疗组大鼠发病率明显降低,炎性病灶明显减少,血清中IFN-γ表达减少。结论黄芪注射液可以改善EAE大鼠的临床症状,减轻脊髓内炎症反应,其作用可能与减少血清IFN-γ的表达水平有关。 Objective To study the effect of astragalus injection on the expression of IFN-γ in rats with experimental autoimmune encephalomyelitis. Methods A Wistar rat EAE model was established by immunizing rats with fresh GPSCH plus complete Freund ＇s Adjuvat（CFA）. Astragalus injection was administered for interventional treatment. The rats were examined for the incidence, the development of neurological signs, changes of histopathology, and the expression of IFN- γ. Results Compared with control group, the rats in astragalus injection treated group showed lower incidence, clegraded morbility, decreased inflammatory reaction, lower level of IFN- γ. Conclusion Astragalus injection can prevent and relieve EAE by decreasing the expression of IFN- γ.
作者 张春阳 石秋艳 田广平 孙原
机构地区 河北联合大学附属医院神经内科 秦皇岛市第二医院神经内科
出处 《中国煤炭工业医学杂志》 2014年第1期115-117,共3页 Chinese Journal of Coal Industry Medicine
基金 河北省2010年医学科学研究重点课题计划(20100473)
关键词 黄芪注射液 实验性自身免疫性脑脊髓炎 干扰素-Γ 大鼠 豚鼠 Astragalus injection Experimental autoimmune encephalomyelitis（EAE） Interferon - γ （IFN - γ） Rat Guinea pigs
分类号 R744 [医药卫生—神经病学与精神病学]
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共引文献18

同被引文献17

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中国煤炭工业医学杂志
2014年 第1期

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