血清可溶性凝集素样氧化低密度脂蛋白受体1早期诊断急性ST段抬高型心肌梗死的价值

The significance of soluble lectin-like oxidized low-density lipoprotein receptor-I on early diagnosis ofacute ST elevation myocardial infarction

目的探讨血清可溶性凝集素样氧化低密度脂蛋白受体1（sLOX．1）早期诊断急性ST段抬高型心肌梗死（STEAMI）的价值。方法入选STEAMI组患者65例，对照组30例为稳定性冠心病或非冠心病的心脏病患者，所有患者入院时立即抽血测定血清sLOX．1。结果STEAMI组血清sLOX．1明显高于对照组[以中位数（P25，P75）表示：210．0（130．0，356．0）ng／L与65．5（55．2，85．2）ng／L，Z=6．17、P〈0．001]，Logistic回归显示血清sLOX-1与STEAMI独立相关（回归系数值为0．036，P〈0．001）。血清sOX．1诊断STEAMI的ROC曲线下面积为0，895，95％CI：0．831—0．959，P〈0．001。以87．5ng／L为截断值，敏感性84．6％，特异性80％。结论sLOX一1在STEAMI时明显升高，具有早期诊断STEAMI的价值。

Objective To investigate whether soluble lectin-like oxidized low-density lipoprotein receptor-1 （sLOX-1） as the early diagnostic biomarker of acute ST elevation myocardial infarction （STEAMI）. Methods Sixty-five patients with STEAMI and 30 patients with stable coranary heart disease or other heart disease（ control group） were enrolled as our subjects. Serum sLOX-1 levels were measured. Results The median（P25 ,P75 ） of Serum sLOX-1 in the patients with STEMI were 210.0 （130.0,356. 0） ng/L,significantly higher than that of control group （65.5 （ 55.2,85.2 ） ng/L, Z = 6. 17, P 〈 0. 001 ）. Logistic regression analysis revealed that sLOX-1 alone was an independent factor associated with STEAMI （ B = 0. 036, P 〈 0. 001 ）. The area under the ROC curve of sLOX-1 for detecting STEMI was 0. 895, and 95% CI was 0. 831 -0. 959 （ P 〈 0. 001 ）. Taking sLOX-1 = 87. 5 ng/L as cut-off value, the sensitivity was 89. 6% and specificity was 82. 4% for the diagnosis of STEAMI. Conclusion Serum sLOX-1 was significantly higher in the STEAMI and it might served as the early diagnostic marker for STEAMI.