2324例门诊患者人乳头瘤病毒感染状况及亚型分析

Infection and Genotype Analysis of Human Papillomavirus among 2324 Outpatients

目的：观察人乳头瘤病毒（ HPV）感染状况并对病毒亚型进行分析，为临床提供诊疗依据。方法对2324例门诊患者进行HPV检测。结果2324例受检者中HPV阳性1528例（65．7％），其中女1314例（56．5％），男214例（9．2％）。女性患者中30～39岁组HPV阳性率最高，达86．2％（467/542），与其他组比较，差异有统计学意义（P＜0．01）；男性以20～29岁组HPV阳性率最高，占54．9％（96/175），与其他组比较，差异有统计学意义（ P＜0．01）。女性与男性均以单一感染为主，分别为50．5％（895/1772）及32．6％（180/552）。HPV的35和43亚型未检出。女性患者高危亚型前4位依次为HPV16（26．9％）、HPV52（15．6％）、HPV58（8．5％）和HPV53（5．0％）；低危亚型以HPV11（8．0％）、HPV6（6．5％）多见。男性感染以低危亚型为主，以HPV11（40．5％）、HPV6（32．0％）多见。高危亚型与低危亚型感染存在性别差异。结论 HPV感染易高发于某一特定的年龄段，女性以30～39岁为主，男性以20～29岁为主，感染类型均以单一感染为主，人群的HPV感染亚型分布具有性别差异。

Objective To investigate the distribution and major subtypes of human papillomavirus （ HPV ） infection,and to provide a basis for clinical treatment .Methods The detection of HPV was performed in 2 324 outpatients. Results Among 2 324 cases,1 528 cases of HPV positive accounted for 65.7%,with 1 314 females（56.5%） and 214 males （9.2%）.In females,the patients aged 30-39 years old showed the highest infection rate （86.2%,467/542）,which was significantly higher than those in the other groups （P〈0.01）.In males,the patients aged 20-29 years old showed the highest infection rate（54.9%,96/175）,which was significantly higher than those in the other groups （P〈0.01）.The single infection was most common in both females and males ,50.5%（895/1 772） and 32.6%（180/552）,respectively.The types of HPV35 and HPV43 were not detected.In females, the top 4 high-risk types were HPV16 （26.9%）, HPV52 （15.6%）,HPV58（8.5%） and HPV53（5.0%）,respectively,while low-risk types were HPV11（8.0%） and HPV6 （6.5%）.The most common types in males were HPV11（40.5%）and HPV6（32.0%）.Significant gender difference was observed in the infection rate between high-risk types and low-risk types.Conclusion The HPV infection is sensitive in the particular age ,as for 30-39 years old in females while 20-29 years old in males .The types of infection are dominated by single infection ,and gender difference can be found in the distribution of HPV subtypes infection .