肝炎后肝硬化并发肝癌的危险因素分析

Risk factors analysis of liver cancer caused by cirrhosis after hepatitis

目的探讨肝炎后肝硬化并发肝癌可能存在的危险因素。方法随机选取我院2006年1月至2013年5月期间肝炎后肝硬化并发肝癌的患者50例为观察组,随机选取肝炎后肝硬化未并发肝癌的患者70例为对照组,回顾性分析两组患者肝炎后肝硬化并发肝癌的危险因素。结果单因素分析结果显示,年龄、饮酒史、糖尿病、HBV、HCV、抗-HBC、抗-HBe、HBs抗原为肝炎后肝硬化并发肝癌的危险因素。将单因素分析有意义的危险因素纳入Logistic多因素回归分析显示,糖尿病为并发肝癌的独立危险因素(OR 1.897,P<0.05);HBs抗原阳性为并发肝癌的独立危险因素(OR 3.346,P<0.05);HBV DNA阳性为并发肝癌的独立危险因素(OR 3.679,P<0.05)。结论肝炎后肝硬化的临床多种危险因素可引起肝癌并发症的发生,其中糖尿病、HBV DNA阳性与HBs抗原阳性是并发肝癌的独立危险因素。

Objective To discuss the risk factors of liver cancer caused by cirrhosis after hepatitis. Methods Fifty patients of liver cancer caused by cirrhosis after hepatitis were selected randomly to be observation group, and 70 patients of hepatitis cirrhosis to be control group. The medical records of the two groups were retrospec-