PKM2在胃癌组织中的表达及其与临床病理特征之间的关系

Expression and clinical significance of PKM2 in human gastric adenocarcinoma

目的探讨PKM2在人胃腺癌组织中的表达及其与临床病理参数之间的关系。方法采用免疫组化SP法检测67例胃腺癌组织、53例癌旁组织中PKM2蛋白的表达及其与临床病例参数之间的关系。结果 PKM2蛋白在胃腺癌组织中的阳性表达(67.2%,45/67)明显高于癌旁组织中PKM2蛋白的表达(28.3%,15/53),PKM2蛋白在胃腺癌组织中的阳性表达与患者的性别、年龄、分化程度均无关(P>0.05),而与患者的淋巴结(χ2=12.103,P=0.001)是否转移与肿瘤侵润深度(χ2=4.030,P=0.045)密切相关。结论 PKM2蛋白在胃腺癌组织中的阳性表达明显高于癌旁组织,且其阳性表达与患者淋巴结与否、肿瘤侵犯深度密切相关,有望成为胃腺癌诊断与治疗的靶向标志物。

Objective To investigate the immunohistochemical expression and diagnostic significance of PKM2 in human gastric adenocarcinoma.Methods Immunohistochemical study was carried out to examine the expression of PKM2 and its association with clinicopathologic features in human gastric adenocarcinoma.Results The positive rate for PKM2 expression in gastric adenocarcinoma tissues （67.2％,45/67） was significantly higher than that in non-tumor tissues （28.3％,15/53）; the positive expression of PKM2 was not correlated with the patient＇s gender,age and histologic differentiation （P＞0.05） except lymph node metastasis （x2=12.103,P=0.001） and tumor invasion （x2=4.030,P=0.045）.Conclusion PKM2 prefers stainning for gastric adenocarcinoma to for non-tumor tissues,and the positive expression was correlated with lymph node metastasis and tumor invasion.