AECOPD患者血清sTREM-1、PCT的变化及意义

Significance of serum sTREM-1 and PCT in patients with AECOPD

目的探讨血清可溶性髓系细胞触发受体-1(sTREM-1)、降钙素原(PCT)在AECOPD细菌性感染早期诊断与严重程度判断上的价值。方法选取AECOPD患者及健康者各40例,于入院当天及经治疗后14天抽取静脉血。采用酶联免疫测定法在同一条件下测定血清sTREM-1、PCT的浓度。经治疗病情相对稳定时测肺功能,根据结果将AECOPD组分成轻中、重、极重度三组,分析上述炎症指标与COPD严重程度的相关性。结果 AECOPD组血清sTREM-1治疗前(92.94±19.24)ng/L、治疗后(90.98±22.17)ng/L浓度均高于正常对照组(83.10±20.60)ng/L,治疗前后血清sTREM-1浓度无明显差别;血清PCT治疗前(644.58±172.11)ng/L、治疗后(575.57±204.09)ng/L浓度均高于正常对照组(509.42±187.09)ng/L,治疗后血清PCT浓度低于治疗前;AECOPD患者血清sTREM-1、PCT浓度与肺功能呈负相关(r=-0.405 r=-0.549)。结论 1.血清PCT可作为AECOPD细菌性感染的早期诊断指标。2.AECOPD患者血清sTREM-1水平与COPD的严重程度可能有一定的相关性。

Objective To investigate the value of serum sTREM-1 and PCT in the early diagnosis of bacteria infectious and judgment on the severity of patients with AECOPD. Methods The levels of serum sTREM-1 and PCT were detected in 40 AECOPD patients and 40 healthy people respectively by ELISA. The AECOPD patients were di- vided into three groups based on their degree of illness. The correlation between the above mentioned indexes and de- grees of illness was analyzed. Results The concentration of sTREM-1 at admission was 92.94 ＋ 19.24 ug/L and 90. 98 ＋ 22. 17 ng/L 15 days after the treatment in serum respectively, which was slightly higher than that in the con- trols without statistical significance. The concentration of PCT at admission was 644. 58 ~ 172. 11 ng/L and 575.57 ＋ 204. 09 ng/L 15 days after the treatment in serum, which was obviously higher than that in the controls with statistics significance. There existed significantly positive correlation between the concentrations of sTREM-1 and PCT and se- verity of COPD （ r = - 0. 405, r = - 0. 549 ）. Conclusion PCT in serum is a good marker in the early diagnosis of bacteria infectious caused by AECOPD. There might exists some relevance between the concentrations of sTREM-1 and PCT in serum and the severity of lung function in patients with AECOPD.