垂体后叶素雾化吸入序贯治疗肺咯血的临床观察

Clinical observation of sequential inhaling pituitrin on hemoptysis

目的观察垂体后叶素静脉滴注后序贯雾化吸入止血治疗的临床反应。方法 42例咯血病人经垂体后叶素静脉滴注24 h,肺咯血部分控制,但仍有中、小量咯血者,随机分为序贯组和对照组,序贯组24例停用静脉滴注后改为垂体后叶素雾化吸入,对照组18例维持静脉滴注治疗,比较两组的止血疗效和不良反应。结果序贯组、对照组的总有效率分别为75.0%(18/24例)、83.3%(15/18例),组间差异无统计学意义(P>0.05);序贯组的不良反应发生率为12.5%,明显少于对照组61.1%,组间差异有统计学意义(P<0.05);序贯组无低钠血症发生,对照组低钠血症4例。结论垂体后叶素持续静脉滴注与雾化吸入序贯治疗肺咯血的临床疗效相当,序贯治疗明显减少平滑肌收缩相关的不良反应,未见低钠血症发生。

Objective To study the clinical efficiency of sequential inhaling pituitrin on hemoptysis. Meth- ods 42 patients with hemoptysis were randomly divided into the sequential group treated with inhaling pituitrin 24 hours after pituitrin infusion and the control group treated with continuous pituitrin infusion. Their efficiency and ad- verse effect were recorded. Results The total effective rate was 75.0% and 83.3% respectively in the sequential group and the control group without significant difference （ P 〉 0.05 ）, The incidence of adverse events in the sequen- tial group was 12. 5 %, which was significantly less than that in the control group of 61.1% （P 〈 0. 05 ）. Conclusion Hemostatic effect of sequential pituitrin inhalation is similar with continuous pituitrin infusion, while the incidence of adverse reactions is obviously lower in the sequential group than that in the control group.