COPD患者高密度脂蛋白胆固醇水平与骨质疏松症的相关性研究

Study on relationship between high density lipoprotein cholesterol and osteoporosis in patients with chronic obstructive pulmonary disease

目的探究慢性阻塞性肺疾病患者高密度脂蛋白胆固醇水平与骨质疏松症的相关性。方法选取COPD患者80例,按照是否继发OP分为观察组及对照组,各40例,进行对比研究。结果观察组BMD、BMC及BMI均显著低于对照组,其HDL-c、IL-6及TNF-α水平明显高于后者;BMD与HDL-c指标呈负相关,且BMC与HDL-c指标呈负相关。结论 COPD患者HDL-c水平越高,骨密度和骨矿质含量越低,骨质状态越差。

Objective To explore the relationship between high density lipoprotein cholesterol and osteopo- rosis in patients with chronic obstructive pulmonary disease. Methods 80 COPD patients, according to the seconda- ry OP, were divided into the observation group and the control group, 40 cases in each group. Results The levels of BMD, BMC and BMI were significantly lower in the observation group than in the control group, and the levels of HDL-c, IL-6 and TNF-α were significantly higher in the observation group than in the control group. BMD was nega- tively correlated with HDL-c, and HDL-c was negatively correlated with BMC. Conclusion The level of HDK-c is negatively correlated with OP in COPD patients. The higher the level of HDL-c is, the lower bone mineral density and bone mineral content are, which lead poor bone status.