烟草对血液尿酸水平的影响

Effects of Tobacco on the Blood Uric Acid

目的:测定吸烟对血液尿酸的影响,并了解这种变化与烟草代谢物的关系。方法:选择健康人群304人,其中吸烟者162人(男145人,女17人),不吸烟者142人(男64人,女78人)。使用全自动生化仪测定血液尿酸、肌酐以及尿中的可替宁水平。结果:吸烟者血液中尿酸水平明显低于不吸烟者,两者有明显差异。血液中尿酸水平降低与吸烟量与时间存在一定负相关关系。结论:在排除影响血液尿酸因素以后,吸烟者尿酸水平明显降低,这种降低与尿酸内源性生成减少有关,是吸烟促发人体应激反应作用的结果。由于测定尿酸方法简单而且能反应人体的抗氧化物水平,它有可能成为吸烟者应激状态的常规检测指标。

Objective ： To determine the effect of smoking on blood uric acid, and to investigate the relationship between the changes of uric acid and the tobacco metabolites. Methods： 304 healthy people were chosen. Among them 162 people （male 145 and female 17） were smokers, and 142 people （male 64 and female 78 ） non-smok- ers. The blood uric acid, creatinine and urinary cotinine were determined by automatic biochemical analyzer. Re- suits： The blood uric acid was significantly lower in smokers than in non-smokers, and there was significant differ- ence between the two groups. Lowering uric acid in the blood was negative correlated with smoking quantity and time. Conclusion： After excluded the other factors affecting blood uric acid, the decrease of uric acid in smokers was attributed to the reduction of endogenous production of uric acid as a result of the chronic exposure to cigarette smoke that was a significant source of oxidative stress. The determination method for uric acid was cheap and sim- ple, and could reflect the level of antioxidant. So it was possible to introduce plasma uric acid estimation as a rou- tine test to understand the smoking stress.