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核心蛋白聚糖发挥抑癌作用的分子机制 被引量：2

Tumor suppressing molecular mechanism of decorin
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摘要 核心蛋白聚糖(decorin,DCN)是由糖胺聚糖链共价连接于核心蛋白所组成的大分子复合物,能够与多种细胞因子结合并发挥抗肿瘤、抑制炎癌转化等生物学功能。它的代谢异常或结构改变与人类肿瘤的发生发展过程密切相关。基于DCN的抗肿瘤活性,重组产品用于人体的免疫原性低,用以抗肿瘤药物的研究具有较好的应用前景。本文结合我们的工作对DCN抑制肿瘤发生发展的分子机制进行综述。
作者 余翔 喻春钊
机构地区 南京医科大学第二附属医院普外科
出处 《解放军医学院学报》 CAS 2014年第2期189-192,共4页 Academic Journal of Chinese PLA Medical School
基金 国家自然科学基金面上项目(30972910 81172269)~~
关键词 核心蛋白聚糖 抗肿瘤 分子机制
分类号 R73-051 [医药卫生—肿瘤]
  • 相关文献

参考文献48

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二级参考文献18

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共引文献3

同被引文献29

  • 1操海萍,舒振波,王维忠,张桂珍.核心蛋白聚糖在乳腺癌中表达的探讨[J].中国肿瘤临床,2006,33(19):1105-1108. 被引量：5
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二级引证文献5

解放军医学院学报
2014年 第2期

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