基于磺酸化聚4-乙烯基吡啶杂多酸盐催化的Biginelli反应

Based on the Biginelli reaction of sulfonated poly catalytic4-vinyl pyridine heteropoly salt

在磺酸化聚4-乙烯基吡啶杂多酸盐的催化作用下,由芳香醛、乙酰乙酸乙酯和脲素三组分一锅法合成3,4-二氢嘧啶-2-酮类化合物,产率可高达96%.催化剂可以通过简单的过滤进行回收循环利用8次,催化活性没有明显的降低.

The poly（4-vinylpyridine）heteropolyacid salts acted as a catalyst to effectively catalyze the threecomponent one-pot synthesis of 3,4-dihydropyrimidin-2 （1H）-ones compounds by ethyl acetoacetate,aldehyde,and urea,and the compounds yield can be obtained in good yields（96％）.More importantly,the catalyst could be easily recovered by the filtration and reused eight times without significant loss of catalytic activity.