阿苯达唑纳米微粉制备工艺研究

On technology of Using liquid phase precipitation method to make albendazole nano powder

目的采用液相沉淀法制备阿苯达唑纳米微粉,分别考察pH值、温度、搅拌速度、超声时间等因素对阿苯达唑纳米微粉制备的影响,以获得最佳的制备工艺。方法以粒径、电位、形貌为指标,运用单因素试验及正交设计,考察pH、制备温度、搅拌速度、超声时间对微粉粒径的影响,并采用扫描电镜、透射电镜及马尔文粒径仪对阿苯达唑纳米微粉进行表征。结果优化工艺制备的阿苯达唑纳米微粉,其平均粒径为213nm,形貌呈不规则粒状,且分布均匀。结论采用液相沉淀法制备工艺可以得到粒径、形貌较好的阿苯达唑纳米微粉。

Objective To investigate the best pH, temperature, stirring speed and ultrasonic time for optimizing the preparation technological conditions by using liquid phase precipitation method to produce albendazole nano powder （The Patent NO. is ZL201010527042.2）. Methods The particle size, zeta-potential, morphology were taken as indicators, to investigate the effects of pH, preparation temperature, stirring speed and ultrasonic time to the particle size of nanocrystalline powders by single factor and orthogonal experiments; TEM, SEM and Malvin particle were analyzed to character albendazole nano powder. Results Using the optimized preparation technology, the average diameter size of albendazole nano powder is 213 nm, zeta-potential 4mv and its appearance irregular granular, well-distributed. Conclusion The preparation process can prepare small size, well-distributed albendazole nano-powder.