盐酸左氧氟沙星治疗盆腔炎的临床安全性分析

Analysis of clinical safety of left-ofloxacin hydrochloride in the treatment of pelvic inflammatory disease

目的探讨盐酸左氧氟沙星治疗盆腔炎的临床安全性。方法将本院96例盆腔炎患者随机分成治疗组与对照组,每组各48例。治疗组给予盐酸左氧氟沙星注射液0.2 g+100 ml生理盐水静脉滴注,对照组给予氧氟沙星注射液0.4 g+100 ml生理盐水静脉滴注,两组均2次/d,7 d为1个疗程,连续2个疗程治疗后,进行疗效及安全性评价。结果治疗组的总有效率为93.8%,高于对照组的79.2%(P<0.05);治疗组出现头痛眩晕2例,恶心1例,腹部不适1例,总不良反应发生率为8.3%,对照组出现头痛眩晕4例,恶心3例,呕吐1例,腹部不适3例,肝功能异常1例,总不良反应发生率为16.7%,治疗组的总不良反应发生率明显低于对照组(P<0.05)。结论盐酸左氧氟沙星治疗盆腔炎临床效果显著,不良反应发生率低且症状轻微,值得推广。

Objective to investigate the clinical safety of levofloxacin hydrochloride in the treatment of pelvic inflam- matory disease （PID）. Methods 96 cases with PID were divided into the treatment group （n=48） and the control group （（n=48）） in our hospital.The treatment group was given 0.2 g levofloxacin hydrochloride injection with 100 ml physio- logical saline of intravenous drip while the control group was given 0.4 g of ofloxacin injection with 200 ml physiologi- cal saline of Intravenous drip.The two groups were administered 2 times ereryday,and 7 days for 1 course.After 2 cours- es,the curative effect and safety was evaluated. Results The total effective rate of the treatment group （93.8%） was higher than that in the control group （79.2%.） （P〈0.05） ;in the treatment group,there were 2 cases with headache and dizziness,1 case with nausea and another 1 case with abdominal discomfort,and the total incidence rate of adverse re- actions was 8.3%;in the same time in the control group,there were 4 cases with headache and dizziness,and 3 cases with nousea,1 case with vomiting,3 cases with abdominal diacomfort,1 case with abnormal liver function,and the total incidence rate of adverse reactions was 16.7%.The total incidence rate of adverse reactions in the treatment group was obviously than that in the control group （P〈0.05）. Conclusion The clinical effect of levofloxacin hydrochloride treating PID is obvious with low incidence rate of adcerse reactions and mild symptoms,so it is worthy of promotion.