盐酸戊乙奎醚、舒芬太尼联合异丙酚在无痛肠镜中的临床应用

Clinical application of penehyclidine hydrochloride,sufentanil combined propofol in the painless colonoscopy

目的观察盐酸戊乙奎醚、舒芬太尼联合异丙酚在无痛肠镜中的临床应用和疗效。方法选择自愿做无痛肠镜检查的患者90例,将其随机分成对照组和观察组各45例,对照组单独给予异丙酚,观察组给予盐酸戊乙奎醚、舒芬太尼联合异丙酚,观察两组的临床效果。结果两组用药前、手术结束时HR、MAP及SpO2比较差异无统计学意义(P>0.05);对照组用药后2 min时HR、MAP、SpO2均明显低于用药前,且与观察组用药后2 min时比较差异有统计学意义(P<0.05);观察组异丙酚用量、苏醒时间均低于对照组[(51.21±9.35)mg vs(105.63±21.54)mg,(1.31±0.89)min vs(3.15±0.57)min](P<0.05),但两组镇静评分差异无统计学意义(P>0.05)。结论结肠镜检查前采用盐酸戊乙奎醚、舒芬太尼联合异丙酚用药,可以增强止痛效果,减少不良反应的发生。

Objective To observe the clinical application and efficacy of penehyclidine hydrochloride,sufentanil com- bined propofol in painless colonoscopy. Methods 90 patients volunteered for painless colonoscopy were randomly divid- ed into control group and observation group,with 45 patients in each group.Patients in the control group were given propofol alone,and patients in the observation group were given penehyclidine hydrochloride,sufentanil combined propo- fol,the effect of the two groups were observed. Results The differences of HR,MAP,SpO2 before treatment and the end of surgery between the two groups were all not statistically significant （P〉0.05）;the levels of HR,MAP and Sp02 in the control group after 2 min treatment were significantly lower than before the treatment,and also lower than those of the observation group（P〈0.05）.the propofol dosage and recovery time of observation group were lower than those of the con- trol group[（51.21±9.35）mg vs （105.63±21.54）mg,（1.31±0.89）min vs （3.15±0.57）min]（P〈0.05）,but the difference of seda- tion score between the two groups was not statistically significant （P〉0.05）. Conclusion The use of penehyclidine hy- drochloride,sufentanil combined propofol can improve the analgesic effect and reduce side effects before colonoscopy.