丹红注射液对脑梗死患者血清IL-8、IL-18和TNF-α浓度的影响

Influence of danhong injection on serum IL-8,IL-18 and TNF-α concentration in patient with cerebral infarction

目的探讨丹红注射液对脑梗死患者血清IL-8、IL-18和TNF-α浓度的影响。方法将60例脑梗死患者分为对照组和观察组,每组30例。对照组采用常规治疗,观察组采用常规治疗联合丹红注射液治疗。应用RIA法和ELISA法分别测定脑梗死患者入院后第1、2、3、5、7天的血清IL-8、IL-18和TNF-α浓度;比较两组疗效。结果观察组总有效率为96.7%,对照组总有效率为53.3%,差异有统计学意义(P<0.05)。入院时,两组血清IL-8、IL-18和TNF-α浓度比较差异无统计学意义(P>0.05)。入院后第1、2、3、5、7天,观察组血清IL-8、IL-18和TNF-α浓度明显低于对照组,差异有统计学意义(P<0.05)。结论丹红注射液可抑制脑梗死患者缺血脑组织的炎症反应,从而改善其神经功能。

Objective To explore influence of danhong injection on serum IL-8,IL-18 and TNF-α concentration in patient with cerebral infarction.Methods 60 patients were divided into control group and observation group,each group of 30 cases.Ordinary therapy was used in control group,ordinary therapy and danhong injection were used in observation group.Serum IL-8,IL-18 and TNF-α concentration of patient with cerebral infarction were measured at days 1,2,3,5 and 7 after admission by RIA or ELISA.The effect of two groups was compared.Results Total effective rate of observa- tion group was 96.7%,total effective rate of control group was 53.3%,with statistical difference （P〈O.05）.At the time of admission,serum IL-8,IL-18 and TNF-α concentration of two groups was compared respectively,with no statistical dif- ferenee（P〉0.O5）.At days 1,2,3,5 and 7 after admission,serum IL-8,IL-18 and TNF-α concentration of observation group was significantly lower than that of control group respectively,with statistical difference （P〈0.05）.Condusion Danhong injection can inhibit inflammatory reaction in ischemie brain tissue of patient with cerebral infarction,so as to improve neurological function.