影响唇鳞癌预后的临床病理因素分析

Clinic pathology prognostic factors in squamous cell carcinoma of lip

目的 研究影响唇鳞癌预后的临床病理因素。方法 以各临床病理指标来研究与唇鳞癌预后有关的因素。结果 1.区域淋巴结转移 :T1 有 5 .4% ,T2 有 6 .5 % ,T3有 41.7%的病例出现区域淋巴结转移 (0 .0 1<P<0 .0 2 5 )。高、中、低分化出现淋巴结转移者分别为 3.6 %、6 .7%和 6 6 .7% (P<0 .0 0 5 )。出现淋巴结转移者的病理核分裂数为 3.2 5个 ,明显高于未出现淋巴结转移 (P<0 .0 1)。而浸润厚度和微血管数与淋巴结转移无关。 2 .术后复发 :复发组浸润厚度为 5 .0 7mm,明显高于无复发组 (P<0 .0 5 ) ;而且复发组的病理核分裂数也明显高于无复发组。高、中、低分化者出现复发的分别为 7.1%、13.3%、5 5 .6 % (P<0 .0 0 5 ) ;从淋巴细胞浸润程度来看 ,两组间无明确关系。结论 肿瘤直径大、分化程度低、病理核分裂数大于 3个时 ,易出现区域淋巴结转移。浸润厚度大于 5 mm、病理核分裂数大于 2个、分化程度低时易出现复发。

WT5”BZ]Objective To study clinic pathology prognostic factors in squamous cell carcinoma of lip. Methods 80 squamous cell carcinoma of lip were analyzed by means of several clinic and pathology factors. And the prognostic factors were showed. Results 1.There were 5.4%, 6.5%, 47.7% cases showed neck metastasis in T 1,T 2,T 3 tumors and 3.6%,6.7%,66.7% in well, middle, poor differentiation tumors respectively. The pathological karyokinesis number was 3.25 in the cases of neck metastasis, and the same time the number showed statistically significant ( P <0 01). 2.The mean thickness of recurrence cases was 5.07mm( P <0.05). There were 7.1%,13.3%,55.6% cases showed recurrence in well, middle, and poor differentiation respectively ( P <0.005). Conclusion Neck metastasis was significantly associated with large tumor size and poor differentiation. It was easy to occur cervical lymph node spreading when the number of pathological karyokinesis was more than three. Further more, Local recurrence was significantly associated with poor differentiation. It was easy to recur when the tumor thickness was more than 5mm and the number of pathological karyokinesis was more than two. Both the number of capillary and the invasion degree of lymph cell were not the related prognostic factors. [WT5”HZ]