血管内皮生长因子对尤文肉瘤的诊断及预后价值

Value of vascular endothelial growth factor in the diagnosis and prognosis of Ewing's sarcoma

目的 研究血清中的血管内皮生长因子（VEGF）在尤文肉瘤中的表达,为尤文肉瘤的诊断及预后的判断提供依据.方法 将本院骨科自2009年1月~2012年11月间18例组织病理学上诊断为尤文肉瘤而尚未进行过放、化疗的患者纳入本研究的病例组,分别收集所有患者化疗前和化疗后的血液样本,测量血清中VEGF的水平.此外,选择20名来本院体检的正常人作为健康对照组,亦检测其血清VEGF水平.结果 18例尤文肉瘤患者平均血清VEGF水平为4547.78 pg/ml,健康对照组为175.8 pg/ml,前者比后者显著升高（P＜0.01）.此外,在进行过新辅助化疗的患者,其化疗后的血清VEGF较化疗前显著下降（P＜0.01）.结论 尤文肉瘤患者的血清VEGF水平显著增高,比较化疗前/后血清VEGF水平,可作为判断患者预后的标志.

Objective To study the expression of vascular endothelial growth factor（VEGF） in Ewingg sarcoma,and to provide reference for its diagnosis and prognosis. Methods Eighteen patients, who were histopathologieally diagnosed as Ewingg sarcoma and had not received chemotherapy or radiotherapy yet between January 2009 and November 2012, were seleeted as the case group. The blood samples of all the patients before and after the chemotherapy were collected, and the level of VEGF in their sera was detected.Furthermore ,20 healthy people who received the health examination in the hospital were selected as control group. And the VEGF level in their sera was also detected. Results The average level of serum VEGF of 18 cases of Ewingg sarcoma was 4547.78 pg/ml, and that of the control group was 175.8 pg/ml. Compared with the latter one, the former significantly increased （P 〈 0.01 ）. Among the patients receiving the neoadjuvant chemotherapy, their levels of serum VEGF significantly decreased after the chemotherapy （ P 〈 0.01 ）. Conclusion The serum VEGF level of the patients with Ewing＇s sarcoma significantly increases. The comparison between the VEGF level before and after the chemotherapy may be used as a marker for the prognosis of those patients.