老年人高尿酸血症的相关危险因素研究

Study on correlative risk factors of hyperuricemia in senile population

目的探讨老年人群中高尿酸血症与肥胖、血压、血脂、血糖的相关关系。方法选择512名60岁以上老年人,男278例,女234例,根据血尿酸检测结果将其分成高尿酸血症组和正常血尿酸组,比较他们的临床资料和生化指标,对影响血尿酸水平的诸因素进行Logistic回归分析。结果与正常尿酸组相比,高尿酸血症组的年龄、体重指数(BMI)、腰臀比、甘油三酯等指标明显增高,高密度脂蛋白则明显降低;Logistic回归分析表明,BMI超标、甘油三酯升高、高龄是影响高尿酸血症发生的主要危险因素。结论随着年龄增长,老年人患高尿酸血症的风险逐渐增加,而BMI、甘油三酯的增高可能增大这种风险。

Objective To explore the correlation between hyperuricemia amd obesity, blood pressure,blood lipids, and blood glucose in senile people. Methods 512 elderly people over 60 years old were enrolled in the study including 278 male and 234 female. According to their examination results of blood uric acid, they were divided into hyperuricemia and normal blood uric acid groups. Comparison was made in the clinical data and biochemical indicators. Logistic regression analysis was made in the factors that affected the blood uric acid level. Results In hyperuricemia group, the BMI, WHR, and triglyceride level all increased significantly, but the high density lipoprotein decreased significantly compared with those indexes of the normal group. The Logistic regression analysis indicated that BMI over standard, increasing triglyceride, and advanced age were the main risk factors that affected the incidence of hyperuricemia. Conclusion Along with the increase of age, the risk of hyperuricemia in senile people is also raised. The increase of BMI and triglyceride maybe augment this risk.