缬沙坦治疗慢性充血性心力衰竭疗效观察

Curative Effect of Valsartan in the Treatment of Chronic Congestive Heart Failure

目的研究缬沙坦治疗慢性充血性心力衰竭的疗效。方法选取我院2011年1月—2013年3月收治的慢性充血性心力衰竭患者80例,按照随机数字法分为对照组(40例)和治疗组(40例),对照组全部患者采取常规治疗措施,治疗组在对照组的基础上采用缬沙坦治疗,比较两组患者的各项指标、临床疗效及不良反应。结果治疗后,治疗组患者LVEF指标高于对照组,收缩压、舒张压、HR低于对照组,差异有统计学意义(P<0.05)。治疗组总有效率为77.5%(31/40),对照组总有效率47.5%(19/40),两组比较差异有统计学意义(P<0.05)。治疗组中头晕1例,无咳嗽;对照组中头晕2例,咳嗽2例。结论缬沙坦能减慢心率,还能降血压,有助于缩小左室内径,另外还能增加患者心搏出量,因此,缬沙坦治疗慢性充血性心力衰竭安全、有效,值得推广。

Objective To explore the curative effect of valsartan in the treatment of chronic congestive heart fail- ure. Methods 80 patients with chronic congestive heart failure treated in our hospital from January 2011 to March 2013 were se- lected. Patients were divided into control group （40 cases ） and treatment group （40 cases ） according to the random num- bers. Control group patients took conventional therapy, on the bases of the control group＇s treatment, the treatment group were given valsartan. The indicators, clinical efficacy and adverse reactions of two groups were compared. Results LVEF of the treat- ment group was higher than control group after treatment （ P 〈 0. 05 ）, but Blood pressure and heart rate were lower than the control group （P 〈 0. 05 ） . The total effective rate of treatment group was 77. 5% （31/40）, which was higher than the control group 47.5% （19/40） （P 〈 0. 05） . Conclusion Valsartan plays a role in slowing heart rate, lowering the blood pressure, help reduce the left ventricular diameter, increases the cardiac output. Therefore, valsartan plays an effective role in improving heart failure patients, which was safe, and worthy of promotion.