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奥氮平对精神分裂症患者血脂血糖及血浆瘦素的影响 被引量:8

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摘要 目的观察奥氮平治疗对精神分裂症患者血糖、血脂及血浆瘦素水平的影响。方法选取2012年我院收治的精神分裂症患者45例,给予奥氮平单药治疗达8周。测量治疗前后体质量,并检测空腹血糖、三酰甘油、总胆固醇、血清脂联素和瘦素水平的变化。结果奥氮平治疗8周后体质量、体质指数、三酰甘油、胆固醇分别为(65.06±9.91)kg、(23.91±3.01)kg/m、(2.15±0.15)mmol/L、(5.91±1.47)mmol/L比治疗前(60.48±9.41)kg、(22.02±2.39)kg/m、(1.26±0.51)mmol/L、(4.63±1.10)mmol/L均升高(P<0.05),治疗后脂联素、瘦素水平分别为(45.14±16.72)ml、(9.55±3.36)ng/m1比治疗前(41.22±16.36)ml、(4.16±5.11)ng/m1升高(P<0.05)。结论奥氮平治疗早期即可出现体质量增加和脂代谢异常,同时血浆瘦素均升高。
作者 苏嵘 罗汝琴
出处 《临床合理用药杂志》 2014年第3期110-111,共2页 Chinese Journal of Clinical Rational Drug Use
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