自发性细菌性腹膜炎腹水TNF-α和IL-6测定的临床意义

The clinical significance of TNF-α and IL-6 measurement in the ascitic fluid in spontaneous bacterial peritonitis.

目的 :探讨肝硬化并自发性细菌性腹膜炎 (SBP)病人腹水中肿瘤坏死因子α(TNF α)和白细胞介素 6 (IL 6 )水平的变化和临床意义。方法 :采用双抗体夹心ELISA法测定48例肝硬化腹水病人血清和腹水的TNF α和IL 6的变化。结果 :在 2 8例SBP病人血清和腹水中TNF α和IL 6水平明显高于 2 0例漏出性腹水病人 (P <0 0 1) ,SBP病人腹水中TNF α和IL 6水平又明显高于血清中的水平。随着感染的控制 ,腹水中TNF α和IL 6水平明显下降 (P <0 0 1)。结论 :腹水TNF α和IL 6的检测有助于SBP的诊断和疗效观察。

Objective:To study the clinical significance of tumor necrosis factor α(TNF α) and interleukin 6(IL 6) levels in ascites of spontaneous bacterial peritonitis (SBP).Methods:TNF α and IL 6 levels from serum and ascitic fluid were measured by ELISA in 48 cirrhotic patients.Results:Serum and ascitic levels of TNF a and IL 6 were higher in 28 patients with SBP ascites compared with 20 patients with transudate(P<0 01).TNF α and IL 6 levels in ascitic fluid was higher than in serum.With treatment of SBP, ascitic TNF α and IL 6 levels decreased(P<0 01)).Conclusion:Measurement of TNF α and IL 6 in ascitic fluidis is helpful for physician to diagnose SBP and to monitor treatment.