吸烟美沙酮维持治疗门诊患者的烟草使用行为与生活质量的关系

Relationship of tobacco use behavior and quality of life among outpatients with methadone maintenance treatment

目的:探索吸烟美沙酮维持治疗(Methadone Maintenance Treatment,MMT)门诊患者的烟草使用行为与生活质量的关系,以验证烟草依赖的"自我治疗假说"。方法:540例吸烟MMT患者完成尼古丁依赖严重程度量表(Fagerstrom Test for Nicotine Dependence,FTND)和中文版世界卫生组织生命质量量表简表(World Health Organization's Quality of Life Questionnaire-Brief Version,Whoqol-BREF)调查,采用多元线性回归分析吸烟量、尼古丁依赖程度和吸烟年限与生活质量评分的关系。结果:多元线性回归分析显示,吸烟量与Whoqol-BREF的生理和心理领域评分负相关(β=-0.155^-0.161,P≤0.004);FTND评分与Whoqol-BREF的4个领域评分负相关(β=-0.339^-0.353,P均<0.001)。结论:吸烟MMT患者吸烟量越大和尼古丁依赖程度越重,生命质量越差,该发现不支持"自我治疗假说"。

Objective ： To explore relationship of tobacco use behavior and quality of life among outpatients with methadone ma- intenance treatment （MMT）, and to test ＂ self-medication hypothesis＂ of tobacco dependence. Methods： Five hundred and forty smokers with MMT were administered with the Chinese version of Fagerstrom test for nicotine dependence （FrND） scale and the world health organization＇s quality of life questionnaire-brief version （Whoqol-BREF）. Multiple linear regression was used to analyze the re- lationships among daily cigarette number, nicotine dependence, smoking history and Whoqol-BREF score. Results： The multiple line- ar regression revealed that the scores of physical and mental domains of Vihoqol-BREF were negatively correlated with daily cigarette number （ β =-0. 155 --0. 161, P≤0. 004） , and the scores of four domains of Whoqol-BREF were negatively correlated with FTND score （ β = -0. 339 - -0.353, all P〈0. 001 ）. Conclusions ： Smokers with MMT with higher daily cigarette number have more severe nicotine dependence and worse quality of life. Moreover, these findings don＇t support the self-medication hypothesis.