宫颈癌发病的年轻化趋势与人乳头状瘤病毒感染的关系

Relationship between human papillomavirus infection and the age of patients with cervical carcinoma

目的 探讨人乳头状瘤病毒感染与宫颈鳞状细胞癌发病年龄的关系。方法 分析 1992年 1月至1999年 10月在我院住院治疗的 75例宫颈鳞癌患者的发病年龄 ,并对其肿瘤组织进行了HPV16E7检测。结果 1992年 1月至 1999年 10月宫颈鳞状细胞癌患者平均发病年龄逐渐减小 ;HPV16的感染率由 2 5 0 0 %上升到48 71%。年轻宫颈鳞癌患者HPV16的感染率 (85 71% )明显高于年龄较大者 (2 8 0 0 % ) (P <0 0 1)。结论 随着HPV16感染率的升高 ,宫颈鳞癌患者年轻化趋势愈明显 ,HPV16感染与宫颈鳞状细胞癌年轻化有关。因此 ,对HPV感染的高危人群应加强监测、随访 ,作到早诊断。

Objective To investigate the relationship between the human papillomavirus infections and the ages of patients with cervical carcinoma.Methods The HPV16E7 was detected by immunohistochemistry in 75 patients of cervical carcinoma from 1992 to 1999 and the ages of them were analysed.Results The ages of the patients gradually became younger from 1992 to 1999;the incidence of HPV16 infection in 1996～1999 was 48 71%,which was significantly higher than 25 00% in 1992～1995(P<0 05).The incidence of HPV16 infections in young women whose age was less than 40 was 85 71%,which was significantly higher than 28 00% in older women(P<0 01).Conclusion The age of cervical carcinoma tends to be young,which is associated with HPV16 infections.The monitoring of HPV infection is important for prevention and early diagnosis of cervical carcinoma in high-risk population.