妊高征孕妇血浆神经肽Y变化的初步研究

Preliminary study of plasma neuropeptide Y in patients with pregnancy induced hypertension

目的 观察妊高征孕妇血浆神经肽Y(NPY)的含量变化。方法 运用放射免疫法检测正常妇女 (正常组 ,17例 ) ,正常妊娠妇女 (正常妊娠组 ,36例 )以及妊高征孕妇 (妊高征组 ,43例 )血浆中PHY的含量。结果 妊高征组患者血浆中NPY的含量显著高于正常妊娠组晚孕妇女 (P <0 0 1)。

Objective To determine the changes of plasma neuropeptide Y(NPY)contents in patients with pregnancy induced hypertension(PIH).Methods The plasma NPY contents in 43 patients with PIH (PIH group),36 healthy pregnant women(pregnancy group) and 17 nonpregnant women(normal group) were measured by radioimmunoassay.Results Plasma NPY contents of PIH group was significantly higher than that of late pregnancy women in pregnancy group(P<0 01).Conclusion Neurohumoral factor plays an important role in the pathogenic mechanism of PIH.and the white matter of the brain after 1 month of CCH, but the amount of the cells was reduced within 2 to 4 months. CsA could alleviate the cell infiltration and the rat cognitive function. Conclusion CsA can inhibit the infiltration of leukocytes and T cells in the brain, attenuate brain injury and improve the cognitive function of rats after CCH. Key words: chronic cerebral hypoperfusion; leukocyte; T cell; rats